Sarcomatoid Renal Cell Carcinoma

Renal cell carcinomas account for about 90 percent of all kidney cancers.

Sarcomatoid renal cell carcinoma.

To get more information on renal cell carcinoma visit the web site of the american cancer society. Webmd medical reference reviewed by minesh khatri md on january 26 2020. Clear cell areas are golden in color due to cellular lipid accumulation while sarcomatoid foci are white. Renal cell carcinoma rcc is the most common malignancy of the kidney and consists of multiple subtypes.

Renal cell carcinoma occurs when cancer cells form in the tubules of the kidney. Sarcomatoid renal cell carcinoma arising from a clear cell renal cell carcinoma lower left. The biggest factor affecting the outlook for kidney cancer is the stage of the disease when it s diagnosed. Current therapeutic approaches are largely ineffective.

Sarcomatoid renal cell carcinoma v arnoux and others prog urology 2013. Definition of sarcomatoid renal cell carcinoma sarcomatoid renal cell carcinoma srcc is currently defined in the 2004 world health organization who classification of renal tumors as any histologic type of renal cell carcinoma rcc containing foci of high grade malignant spindle cells. Volume 23 issue 7 pages 430 7. Renal cell carcinoma rcc with sarcomatoid differentiation belongs to the most aggressive clinicopathologic phenotypes of rcc.

Sarcomatoid transformation in renal cell carcinoma so called sacromatoid rcc srcc is associated with an aggressive behavior and a poor prognosis. The sarcomatoid variety while previously considered a distinct histologic subtype is now categorized as a form of dedifferentiated carcinoma. It is characterized by a high propensity for primary metastasis and limited therapeutic options due to its relative resistance to established systemic targeted therapy. Sorafenib after combination therapy with gemcitabine plus doxorubicine in patients with sarcomatoid renal cell carcinoma.

Volume 15 pages 287 to91. A prospective evaluation m staehler and others european journal of medical research 2010. Many studies have defined a tumor as srcc if even a.